05 Nov 2026

9.5 Primary Pyomyositis

Type of Infection First Line
(with Dosage and Duration)
Alternative First Line
(with dosage and Duration)
Comments
Primary Pyomyositis Amoxicillin- clavulanic acid 1g+200 mg q8h IV) Or Cefalexin 500 mg q8h per oral Or Inj Cloxacillin 2g q6h IV Or 500 mg q6h per oral Or Inj Cefazolin 1g q8h Duration: 48-72 hours after clinical improvement and adequate source control In case of primary pyomyositis with features of sepsis, consider Inj Piperacillin- tazobactam 4.5g q6h + Inj Vancomycin 15- 20 mg/kg/day every 8 to 12 hours. Duration: 48-72 hours after clinical improvement and adequate source control Optimize antibiotics based on pus culture and susceptibility report.

For common etiological agents of Primary Pyomyositis, see Annexure B.9.5