6.10 Chorio-amnionitis
| Type of Infection | First Line (with Dosage and Duration) |
Alternative First Line (with dosage and Duration) |
Comments |
|---|---|---|---|
| Chorio-amnionitis | Ampicillin 2g IV q6h + Gentamicin 5 mg/kg daily OD IV + Metronidazole 500mg IV q8 h Or Amoxicillin-clavulanic acid 1.2g q8h for 7-10 days | Clindamycin 600 IV q8h + Gentamicin 5 mg/kg daily IV for 7-10 days | |
| Chorio-amnionitis (Sepsis) | Inj Piperacillin-tazobactam 4.5g IV q6h for 7-14 days | Imipenem 500mg IV q6h / Meropenem 1-2g IV q8h +/- Amikacin 15 mg/kg IV OD for 7-10 days | If the patient is in septic shock, consider adding Vancomycin or Teicoplanin to cover MRSA. |
For common etiological agents of Chorio-amnionitis, see Annexure B.6.10
References
1. Guidelines for the management of symptomatic sexually transmitted infections. Geneva: World Health Organization; 2021. Licence: CC BY-NC-SA 3.0 IGO. Available from: https://iris.who.int/bitstream/handle/10665/342523/9789240024168-eng.pdf?sequence=1
2. STI Guidelines 2021, CDC, MMWR Recomm Rep 2021;70(4). Available from: https://www.cdc.gov/std/treatment-guidelines/STI-Guidelines-2021.pdf