4.1 Oesophagitis
| Type of Infection | First Line (with Dosage and Duration) |
Alternative First Line (with dosage and Duration) |
Comments |
|---|---|---|---|
| Oesophagitis | Fluconazole 6- 12mg/kg (200-400 mg orally or IV on day 1 then 200 to 400 mg daily) for 2 weeks | Itraconazole 200 mg per day orally for 14 days | Most common cause of Oesophagitis is Candida, followed by HSV and CMV. Oesophageal Candidiasis can be picked up by endoscopic examination, HSV and CMV requires histopathology examination. Rule out immunocompromised condition (eg: HIV), if clinical diagnosis of esophagitis is made. Minimize or discontinue the use of broad-spectrum antimicrobial agents and immunosuppressants. |
For common etiological agents of Oesophagitis, see Annexure B.4.1
References
1. Andrew Chao, Jose A. Vazquez, Fungal Infections of the Gastrointestinal Tract, Gastroenterology Clinics of North America, Volume 50, Issue 2, 2021, Pages 243-260. Available from: https://doi.org/10.1016/j.gtc.2021.02.009
2. Mohamed AA, Lu XL, Mounmin FA. Diagnosis and Treatment of Esophageal Candidiasis: Current Updates. Can J Gastroenterol Hepatol. 2019 Oct 20; 2019:3585136. doi: 10.1155/2019/3585136. PMID: 31772927; PMCID: PMC6854261