18.2 Invasive Candidiasis
| Type of Infection | First Line (with Dosage and Duration) |
Alternative First Line (with dosage and Duration) |
Comments |
|---|---|---|---|
| Invasive candidiasis | Echinocandins (caspofungin, anidulafungin, or micafungin) are recommended as first-line agents, regardless of the underlying disease. Micafungin 100 mg IV daily Or Anidulafungin loading dose 200 mg, then 100 mg daily Or Caspofungin loading dose 70 mg, then 50 mg daily Or Fluconazole PO/IV 800mg (12 mg/kg) loading dose, then 400 mg (6 mg/kg) daily (can choose fluconazole if patient is stable and azole resistant candida (like C. glabrata, C. auris and C. krusei) are not commonly seen in particular health care facility | Liposomal Amphotericin B 3–5 mg/kg daily | Transition from echinocandins to fluconazole is recommended after 5–7 days among patients who have isolates that are susceptible to fluconazole, who are clinically stable, and in whom repeat cultures on antifungal therapy are negative. |
For common etiological agents of Invasive Candidiasis, see Annexure B.18.2
References
1. Mehta Y (2024) Challenges in the Diagnosis and Treatment of Invasive Candidiasis in India. Int J Crit Care Emerg Med 10:165. doi.org/10.23937/2474-3674/151016.