17.3 Infections in Asplenia
| Type of Infection | First Line (with Dosage and Duration) |
Alternative First Line (with dosage and Duration) |
Comments |
|---|---|---|---|
| Acute onset undifferentiated fever | Ceftriaxone 2g IV q 12h Duration: 7 days | Cefotaxime 2g IV q8h Or Amoxicillin- clavulanic acid 1.2g IV q8h Duration: 7 days | Consider following the approach in acute undifferentiated fever section |
| Community acquired sepsis | Refer to section on community onset sepsis |
For common etiological agents of Infections in Asplenia, see Annexure B.17.3
Additional Information
- Patient education, vaccination and antibiotic chemoprophylaxis are recommended for all individuals with asplenia to prevent infections.
References
1. Grace M. Lee; Preventing infections in children and adults with asplenia. Hematology Am Soc Hematol Educ Program 2020; 2020 (1): 328–335. doi:
2. Tahir F, Ahmed J, Malik F. Post-splenectomy Sepsis: A Review of the Literature. Cureus. 2020 Feb 6;12(2):e6898. doi: 10.7759/cureus.6898. PMID: 32195065; PMCID: PMC7059871.
3. Davidson RN, Wall RA. Prevention and management of infections in patients without a spleen. Clin Microbiol Infect. 2001 Dec;7(12):657-60. doi: 10.1046/j.1198-743x.2001.00355. x. PMID: 11843905.