05 Nov 2026

16.1 Odontogenic tooth infections

Type of Infection First Line
(with Dosage and Duration)
Alternative First Line
(with dosage and Duration)
Comments
Gingivitis Not required Not required Since it is a localized and superficial infection, it requires oral hygiene maintenance and scaling of teeth (only in few cases).
Periodontitis Metronidazole 400mg q8h If the local treatment and 5 days course of Metronidazole 400mg q8h is not effective surgical treatment is required. In very few cases:Amoxicillin 1g q8h may be advised. Local treatment (scaling of teeth, pocket treatment) and removal of causative agent. In case patient is diabetic, adequate glycemic control will help in improving.
Complicated (severe infections, immunocompromised/ neutropenic etc) eg Ludwig’s Angina, Odontogenic Sinusitis, Cavernous Sinus Thrombosis, Brain Abscess etc. Metronidazole 400mg q8h + Amoxicillin 1g q8h may be advised. Amoxicillin- clavulanic acid 1g q12h Removal of cause of the complication will help. (improving immune status and neutrophil counts)

For common etiological agents of Odontogenic tooth infections, see Annexure B.16.1

Additional Information

  • Apart from gingiva, the infections involving pulp may reach via tooth root to the jaw bone and can cause peri-apical infections. However, all pulp infections should be treated by doing root canal treatment and debridement. In rare cases when peri-apical infection spreads to other soft tissue planes and cause systemic symptoms like fever, malaise and extensive swelling then they can be treated with systemic antibiotics.

References

1. Tahmasebi, E.; Keshvad, A.; Alam, M.; Abbasi, K.; Rahimi, S.; Nouri, F.; Yazdanian, M.; Tebyaniyan, H.; Heboyan, A.; Fernandes, G.V.O. Current Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology. Life 2023, 13, 269. Available from: https://doi.org/10.3390/life13020269
2. https://my.clevelandclinic.org/health/treatments/antibiotics-for-tooth-in