05 Nov 2026

10.4 Septic arthritis

Type of Infection First Line
(with Dosage and Duration)
Alternative First Line
(with dosage and Duration)
Comments
Septic Arthritis Antibiotic selection is same as that for acute osteomyelitis. Duration of therapy: 4-6 weeks for adults, 2 weeks for Gonococcal arthritis (monoarticular arthritis in those with risk of STD). Ceftriaxone 1g q24h for 2 weeks Acute septic Arthritis (in hip joints) may be secondary to osteomyelitis of proximal femur; Duration of therapy may be 3-6 weeks. Acute septic arthritis of hip joint is an emergency condition that often requires early decompression of hip joint with early initiation of antibiotics to avoid Tom Smith arthritis.

For common etiological agents of Septic arthritis, see Annexure B.10.4

References

1. Ringold, S., Angeles-Han, S.T., Beukelman, T., Lovell, D., Cuello, C.A., Becker, M.L., Colbert, R.A., Feldman, B.M., Ferguson, P.J., Gewanter, H., Guzman, J., Horonjeff, J., Nigrovic, P.A., Ombrello, M.J., Passo, M.H., Stoll, M.L., Rabinovich, C.E., Schneider, R., Halyabar, O., Hays, K., Shah, A.A., Sullivan, N., Szymanski, A.M., Turgunbaev, M., Turner, A. and Reston, J. (2019), 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Arthritis Rheumatol, 71: 846- 863. https://doi.org/10.1002/art.40884