Dosage of common antibiotics used in treatment of MDR Organisms
| Antibiotics | Dosage in adults |
|---|---|
| Ceftazidime-avibactam and aztreonam | Ceftazidime-avibactam: 2.5 g IV q8h, infused over 3 hours PLUS aztreonam: 2 g IV q8h, infused over 3 hours |
| Colistin | 9 million units as loading dose and then 4.5 million units q12h |
| Polymyxin B | 15 lacs IU as loading dose and then 7.5 lacs IU q12h. |
| High dose meropenem | 2 g IV q8h, infused over 3 hours |
| High dose imipenem | 1g IV q6h, infused over 2 hours |
| Tigecycline | 200 mg IV x 1 dose, then 100 mg IV q12h |
| Minocycline | 200mg IV q12h |
| Sulbactam | 2g IV q6 - 8h |
| IV Fosfomycin | 4-6g IV q6h |
| High dose ampicillin-sulbactam (2g of ampicillin and 1 gm of sulbactam) | 9g IV q8h over 4 hours |
| Cefoperazone-sulbactam (1g/1g) | 2g IV q8h |