Doses of drugs used in CNS infections
Drug |
Adult dose |
Paediatric dose |
|---|---|---|
| Artesunate | 2.4 mg/kg 0,12 and 24 hours and then q 24 hourly | < 20 kg 3 mg/kg at 0,12 and 24 hours and then q 24 hourly |
| Acyclovir | 10 mg/kg 8 hourly | 10 mg/kg 8 hourly and in children below 12 20 mg/kg 8 hourly |
| Ceftriaxone | 2 gm 12 hourly | 50 mg/kg 12 hourly |
| Ceftazidime | 2 gm q 6-8 hourly | 50 mg/kg 8 hourly |
| Cefepime | 2 gm 8-12 hourly | 50 mg/ kg 12 hourly |
| Cefotaxime | 2 gm 6 hourly | 50 mg/kg 6 hourly |
| Meropenem | 2 gm 8 hourly | 40 mg/kg 8 hourly |
| Colistin | 9 million unit loading and then 4.5 million units 12 hourly | 150,000 units/ kg loading and then 75000 units/kg 12 hourly |
| Polymyxin B | 20000- 25000 units/kg loading and then 12500 to 15000 units/kg 12 hourly, single dose not to exceed 20,00,000 units | 15-25,000 units/ kg loading and then 5000-7500 units/ kg 8 hourly |
| Fosfomycin | 4 gm 6 hourly | 75-100 mg/kg/dose 6 hourly |
| Cotrimoxazole | 3-6 mg/kg of TMP thrice daily | |
| Vancomycin | 15 mg/kg (max 2 gm)eight hourly | 15 mg/kg 6 hourly |
| Cloxacillin | 2 gm 4 hourly | 50 mg/kg 6 hourly |
| Doxycycline | 100 mg 12 hourly | 1.5-2 mg/kg 12 hourly |
| Chloramphenicol | 1-2 gm 6 hourly | 25 mg/kg 6 hourly |
| Rifampicin | 600 mg once daily | 10-20 mg/kg once daily |
| Metronidazole | 400 mg 8 hourly | 10 mg/kg 8 hourly |
| Amphotericin B deoxycholate | 1 mg/kg/day | |
| Liposomal amphotericin B | 3-5 mg/kg/day | |
| Fluconazole | 800 mg loading and then 400 mg once daily | 12 mg/kg loading and then 6 mg/ kg daily 25 mg/kg loading in neonates and then 12 mg/kg daily |