Definitive antimicrobial treatment for IE

Staphylococcus aureus

Antibiotic therapy for due to Staphylococcus aureus *
Etiologies (usual) Suggested Regimens (Primary) Adjunct Diagnostic or Therapeutic Measures or comments
Native valve MSSA IE Cloxacillin 12gm/day
in three divided doses for 6 weeks 		Flucloxacillin (200 -300 mg/kg/day in 4-6 equally divided doses)or
Cefazolin  Paediatric dose is  30-100 (60 mg/kg/day) in three divided doses for 6 weeks
Prosthetic valve MSSA IE Cloxacillin 12gm/day in three divided doses,
With Rifampicin  max dose 900 mg for 6 weeks with
Gentamicin 1mg/kg TDS for 2 weeks 		Flucloxacillin (200 -300 mg/kg/day in 4-6 equally divided doses) with
Rifampicin Paediatric 15 mg/kg/day in three divided doses, max dose 900 mg for 6 weeks with
Gentamicin 1mg/kg TDS for 2 weeks
Native valve MRSA IE Vancomycin  for 6 weeks Daptomycin *
for 6 weeks
Prosthetic valve MRSA IE- Vancomycin  with Rifampicin  in three divided doses, max dose 900 mg for 6 weeks  with
gentamicin 1mg/kg TDS for 2 weeks		 Daptomycin
for 6 weeks
with rifampicin Paediatric 15 mg/kg/day in three divided doses, max dose 900 mg for 6 weeks  with
gentamicin 1mg/kg TDS for 2 weeks

* Vancomycin Doses mentioned

** Daptomycin dose for right sided IE is 6 mg/kg/dose and for left-sided IE or complicated IE is 8-10 mg/kg/dose