IE caused by Coagulase-Negative:
Coagulase-Negative Staphylococci (CoNS) in the presence of prosthetic valves or other prosthetic material can cause infective endocarditis. It can be the etiological agent for IE even in native valve if it’s isolated in multiple blood cultures like in patients on hemodialysis (HD) with an HD catheter or central venous catheter (CVC). CoNS that cause PVE usually are methicillin resistant, particularly when IE develops within 1 year after surgery. Treatment recommendations for IE caused by MR CoNS is illustrated
IE caused by Coagulase-Negative Staphylococci
| Etiologies (usual) | Suggested Regimens (Primary) |
|---|---|
| Native valve MR CoNS IE | Vancomycin (30mg/kg/day in two divided doses) for 6 weeks |
| Prosthetic valve MR CoNS IE- | Vancomycin (30mg/kg/day in two divided doses) with rifampicin in three divided doses, max dose 900 mg for 6 weeks with gentamicin 1mg/kg TDS for 2 weeks |