Severe sepsis and septic shock of unknown source

Severe sepsis and septic shock of unknown source

Severe sepsis and septic shock of unknown source

Clinical condition	Common pathogens	Empirical antimicrobial agents	Comments
Community acquired	Enterobacteriaceae, P. aeruginosa, S. aureus	Imipenem-cilastatin  or meropenem	Add vancomycin if S. aureus is a concern. Add colistin or polymyxin B if risk factors
Hospital acquired	Enterobacteriaceae, P. aeruginosa, Acinetobacter spp, S. aureus	Imipenem or meropenem plus polymyxin B or colistin plus vancomycin

 

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