Skin and soft tissue infections
Skin and soft tissue infections
| Clinical condition | Common pathogens | Empirical antimicrobial agents | Alternative antimicrobial agents | Comments |
|---|---|---|---|---|
| Cellulitis | S. pyogenes, S. aureus (MSSA) | Cefazolin | Clindamycin | Shift to oral when improving |
| Abscess, carbuncle | S. aureus | Clindamycin | Linezolid | Cover for MRSA till sensitivities back |
| MSSA | Cefazolin | |||
| MRSA | Vancomycin | Clindamycin | ||
| Necrotizing fascitis | S. pyogenes, S. aureus, anaerobes, Enterobacteriaceae | Piperacillin-tazobactam or Cefoperazone-sulbactam plus Clindamycin |
Imipenem-cilastatin or meropenem plus Clindamycin |
Early surgical debridement essential |