Continue no longer than 24 hours postoperatively
- Most studies have demonstrated efficacy of peri-operative antibiotic prophylaxis for only 12 hours or less. Whenever short and long courses are compared, the shorter course has proven equally effective. A single dose is as effective as multiple doses, and antimicrobial prophylaxis after wound closure is unnecessary.
- Prolonged antibiotic prophylaxis beyond 48 hours is not only ineffective in reducing infections but increases antimicrobial resistance and the risk of infection with Clostridium difficile.