• Catheter removal is essential.
• Antifungal therapy is recommended for all cases of CLABSI due to Candida species.
• Treat 14 days after first negative blood culture result or resolution of signs and symptoms associated with candidemia, whichever is longer.
• The ophthalmological examination is recommended for all patients.

CLABSI due to Gram positive cocci and suggested antibiotics

Etiology	Suggested regimens		Etiology
	Preferred	Alternative
Candida species (unspeciated)/ C. albicans, C. tropicalis/ C. parapsilosis	Micafungin 100 mg IV daily Or Anidulafungin loading dose 200 mg, then 100 mg daily Or Caspofungin loading dose 70 mg, then 50 mg daily Or Fluconazole 800-mg loading dose, then 400 mg daily	Amphotericin B (lipid) 3–5 mg/kg daily Or Amphotericin B deoxycholate- 0.5–1 mg/kg daily Or Voriconazole 400 mg (6 mg/kg) q12h for 2 doses then 200 mg (3 mg/kg ) q12h	Fluconazole may be used as a preferred agent/ step down agent after 5-7 days of initial echinocandin therapy if the isolate is susceptible; the patient has no previous azole exposure and is not critically ill.
C. auris/ C. haemulonii/ C. krusei	Micafungin 100 mg daily; Or Anidulafungin loading dose 200 mg, then 100 mg daily	Voriconazole 400 mg (6 mg/kg) bid for 2 doses then 200 mg (3 mg/kg ) bid
C. glabrata	Voriconazole 400 mg (6 mg/kg) bid for 2 doses then 200 mg (3 mg/kg ) bid Or Micafungin 100 mg daily; Or Anidulafungin loading dose 200 mg, then 100 mg daily	Fluconazole (step down) 800 mg daily Or Amphotericin B (lipid)	Fluconazole may be given as step down therapy in high dose if MIC favourable.